Symbol
Name
ID

Atm
ataxia telangiectasia mutated
MGI:107202

Phenotype annotations related to endocrine/exocrine glands

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Hypoplasia of the thymus	Exocrine pancreatic insufficiency	Pancreatic adenocarcinoma	Goiter	Non-medullary thyroid carcinoma	Papillary thyroid carcinoma	Delayed puberty	Female hypogonadism
Disease(s) Associated with ATM	Diabetes mellitus	Hypoplasia of the thymus	Exocrine pancreatic insufficiency	Pancreatic adenocarcinoma	Goiter	Non-medullary thyroid carcinoma	Papillary thyroid carcinoma	Delayed puberty	Female hypogonadism
ataxia telangiectasia
pancreatic cancer
thyroid gland papillary carcinoma

Mouse Phenotypes

thymus cortex hypoplasia

small thymus

decreased thymocyte number

absent ovarian follicles

small ovary

ovary degeneration

abnormal testis morphology

abnormal seminiferous tubule morphology

seminiferous tubule degeneration

abnormal testis development

small testis

increased ovary tumor incidence

increased T cell derived lymphoma incidence

Availability

Mouse Genotype

Atm^tm1.1Mmpl/Atm^tm1.1Mmpl

Atm^tm1Awb/Atm^tm1Awb

Atm^tm1Bal/Atm^tm1Bal

Atm^tm1Fwa/Atm^tm1Fwa

Atm^tm1Led/Atm^tm1Led

Atm^tm1Mfl/Atm^tm1Mfl

Atm^tm1Mfl/Atm⁺

Atm^tm2.1Fwa/Atm^tm2.1Fwa
Tg(VAV1-cre)1Graf/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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